Engineering a human IgG2 antibody stable at low pH
نویسندگان
چکیده
منابع مشابه
Human IgG2 antibody disulfide rearrangement in vivo.
Proteins destined to circulate in the blood are first folded and assembled in the endoplasmic reticulum of secretory cells. For antibodies, like many other serum proteins, the folding and assembly steps involve the formation of disulfide bonds. Such bonds have been thought to be static features of proteins, stabilizing domains, and linking polypeptide chains, although some cases of extracellula...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2020
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.3852